RDB01748 - AxCANCre

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AxCANCre

Recombinant adenovirus expressing recombinase Cre with nuclear localization signal

Catalog number	RDB01748
Resource name	AxCANCre
Alternative name
Clone info.	Recombinant adenovirus expressing the recombinase Cre tagged with a nuclear localization signal under the control of CAG promoter.
Vector backbone	pAxcw (Adenovirus)
Size of vector backbone	-
Growth remarks	5 percent FCS is fine.
Gene/insert name	P1 phage Cre recombinase cDNA
Depositor\|Developer	Saito, Izumu \|

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External Database
P1 phage Cre recombinase

NCBI Gene

Reference sequence

Distribution information

Please check terms and conditions set forth by the depositor, which are specified in the RIKEN BRC Catalog and/or Web Catalog.

Terms and conditions set forth by the DEPOSITOR In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of literature designated by the DEPOSITOR is requested (Kanegae, Y., Nucleic Acids Res., 23, 3816-3821(1995)).

Additional terms and conditions for distribution Regarding resources containing CAG promoter: In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation for the CAG promoter (Niwa, H., Yamamura, K., Miyazaki, J., Gene 108 : 193-200, 1991) and an acknowledgment to Dr. Jun-ich Miyazaki of the Osaka University are requested.

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Material Transfer Agreement (MTA for use for not-for-profit academic purpose) [Word]

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Terms and conditions set forth by the DEPOSITOR	In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of literature designated by the DEPOSITOR is requested (Kanegae, Y., Nucleic Acids Res., 23, 3816-3821(1995)).
Additional terms and conditions for distribution	Regarding resources containing CAG promoter: In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation for the CAG promoter (Niwa, H., Yamamura, K., Miyazaki, J., Gene 108 : 193-200, 1991) and an acknowledgment to Dr. Jun-ich Miyazaki of the Osaka University are requested.
Ordering	Please visit Information of Request for Distribution.[link] Order form [Credit Card Payment] [Bank Transfer Payment] Material Transfer Agreement (MTA for use for not-for-profit academic purpose) [Word]

提供条件	利用者は、研究成果の公表にあたって寄託者の指定する文献を引用する (Kanegae, Y., Nucleic Acids Res., 23, 3816-3821(1995))。
付加的提供条件	CAGプロモータを含むリソースについて: 利用者は、研究成果の公表にあたってCAGプロモータの文献 (Niwa, H., Yamamura, K., Miyazaki, J., Gene 108 : 193-200, 1991)を引用し、大阪大学宮崎純一博士への謝辞の表明を必要とする。
提供依頼	手続きの詳細は、「提供申込みについて[link]」をご覧ください。提供依頼書 [Word] 提供同意書 (MTA、非営利機関による非営利学術研究用)[Word] 遺伝子組換え生物の受入れ確認書 [Word]
備考	【追加提供依頼書】受入れ確認書(書式J) 組換え体提供にかかる書式が必要です。

Catalog #	Resource name	Shipping form	Fee (non-profit org.)
RDB01748	AxCANCre	Virus, lysate of infected cell culture

Ordering Information [in Japanese] [in English]
Please review the QC test results indicated by check

icon below as well as clone information before placing your order.

References and tips

Electronic file

Remarks, protocol and/or map (gif)	RDB01748.gif

Original reference

original	Kanegae, Y., Efficient gene activation system on mammalian cell chromosomes using recombinant adenovirus producing Cre recombinase. Gene, 181, 207-212 (1996). PMID 8973332.
original	Kanegae, Y., Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res., 23, 3816-3821 (1995). PMID 7479022.

Further references such as user reports and related articles (go to bottom)

Featured content	Dnaconda's recommendation EXR0066e (English text)
Featured content	Dnaconda's recommendation EXR0066j (Japanese text)
Featured content	Control Vectors (English text)
Featured content	Cre-loxP and FLP-FRT System (English text)

Sequence information

RIKEN BRC has sequenced portions of this material for quality test.
Please review the QC test results indicated by check icon as well as clone information before placing your order.

Test sheet	RDB01748_020904p2-1.pdf

Nucleotide sequence of a portion of this resource (if available).

Primer: pCAG-F Sequence file: RDB01748_020904a.seq
>01748_01748_A6C4_2_pCAG-F_B01_02_ABI08.ab1 1 GCTGGGGGGG AAAGCTGCCT TCGGGGGGGA GGGGCAGGGC GGGGTTCGGC TTCTGGCGTG 61 TGACCGGCGG CTCTAGAGCC TCTGCTAACC ATGTTCATGC CTTCTTCTTT TTCCTACAGC 121 TCCTGGGCAA CGTGCTGGTT ATTGTGCTGT CTCATCATTT TGGCAAAGAA TTGATTTATC 181 GATTTGCAGA CCGTGCATCA TGAGCGGCCC TCCAAAAAAG AAGAGAAAGG TAGAAGACCC 241 GGGCGGCCGC ATGTCCAATT TACTGACCGT ACACCAAAAT TTGCCTGCAT TACCGGTCGA 301 TGCAACGAGT GATGAGGTTC GCAAGAACCT GATGGACATG TTCAGGGATC GCCAGGCGTT 361 TTCTGAGCAT ACCTGGAAAA TGCTTCTGTC CGTTTGCCGG TCGTGGGCGG CATGGTGCAA 421 GTTGAATAAC CGGAAATGGT TTCCCGCAGA ACCTGAAGAT GTTCGCGATT ATCTTCTATA 481 TCTTCAGGCG CGCGGTCTGG CAGTAAAAAC TATCCAGCAA CATTTGGGCC AGCTAAACAT 541 GCTTCATCGT CGGTCCGGGC TGCCACGACC AAGTGACAGC AATGCTGTTT CACTGGTTAT 601 GCGGCGGATC CGAAAAGAAA ACGTTGATGC CGGTGAACGT GCAAAACAGG CTCTAGCGTT 661 CGAACGCACT GATTTCGACC AGGTTCGTTC ACTCATGGAA AATAGCGATC GCTGCCAGGA 721 TATACGTAAT CTGGCATTTC TGGGGATTGC TTATAACACC CTGTTACGTA TAGCCGAAAT 781 TGCCAGGATC AGGGTTAAAG ATATCTCACG TACTGACGGT GGGAGAATGT TAATCCATAT 841 TGGCAGAACG AAAACGCTGG TTAGCACCGC AGTGTAGAGA AGGCACTTAG CCTGGGGGGT 901 AACTAAACTG GTCGAGCGAT GGATTTCCGT CTCTGGTGTA GCTGATGATC CGAATAACTA 961 CCCTGTTTTG CTGATCAGAA AAAAATGGGT GTTTGCCCGC GCCATCTGCC ACAGCCCAGG 1021 CTATCCACTT CGCGCCCCTG GGAAAGGATT TTGGAGGCCA ACTCATCCGA ATTGGATTAC 1081 GCGCTAGAAT GACTCTGGTT CAGGAGATAC CTGTGGTC //
Primer: pAxcwit2_Rv Sequence file: RDB01748_020904b.seq
>01748_01748_A6C4-7_3_pAxcwit2_Rv_B02_05_ABI24.ab1 1 TTGGGCACTG CATAGAAGAG TGAATCTGAA TAATTTTGTG TTACTCATAG CGCGTAATAT 61 TTGTCTAGGG CCGCGGGGAC TTTGACCGTT TACGTGGAGA CTCGCCCAGG TGTTTTTCTC 121 AGGTGTTTTC CGCGTTCCGG GTCAAAGTTG GCGTTTTATT ATTATAGTCA GCATCGTTTA 181 AACAGCTTGG GCCCTCGAGG GGTCGAGGGA TCTCCATAAG AGAAGAGGGA CAGCTATGAC 241 TGGGAGTAGT CAGGAGAGGA GGAAAAATCT GGCTAGTAAA ACATGTAAGG AAAATTTTAG 301 GGATGTTAAA GAAAAAAATA ACACAAAACA AAATATAAAA AAAATCTAAC CTCAAGTCAA 361 GGCTTTTCTA TGGAATAAGG AATGGACAGC AGGGGGCTGT TTCATATACT GATGACCTCT 421 TTATAGCCAA CCTTTGTTCA TGGCAGCCAG CATATGGGCA TATGTTGCCA AACTCTAAAC 481 CAAATACTCA TTCTGATGTT TTAAATGATT TGCCCTCCCA TATGTCCTTC CGAGTGAGAG 541 ACACAAAAAA TTCCAACACA CTATTGCAAT GAAAATAAAT TTCCTTTATT AGCCAGAAGT 601 CAGATGCTCA AGGGGCTTCA TGATGTCCCC ATAATTTTTG GCAGAGGGAA AAAGATCTCA 661 GTGGTATTTG TGAGCCAGGG CATTGGCCAC ACCAGCCACC ACCTTCTGAT AGGCAGCCTG 721 CACCTGAGGA GTGAATTGAT TATCGATTCT AGACTAGTTT AATTAATTTC TAGAGCGCTT 781 AATGGCTAAT CGCCATCTTC CAGCAGGCGC ACCATTGCCC CTGTTTCACT ATCCAGGTTA 841 CGGATATAGT TCATGACAAT ATTTACATTG GTCCAGCCAC CAGCTTGCAT GATCTCCGGT 901 ATTGAAACTC CAGCGCGGGC CATATCTCGC GCGGCTCCGA CACGGGCACT GTGTCCAGAC 961 CAGGCCAGGT ATCTCTGACC AGAGTCATCC TTAGCGCCGT AAATCAATCG ATGAGTTGCT 1021 TCAAAAATCC CTTCCAGGCG CGAGTTTGAT AGCTGGCTGG GTGGCAGATG GCGCGGCAAC 1081 ACCATTTTTT CCTGAACTCG CAAACAGTTA GGTTATTCGG ATCATCCAGG CCTTAACAAC 1141 CCAGGACAG //
Primer: pAxCA_R1 Sequence file: RDB01748_020904c.seq
>01748_01748_A6C4_2_pAxCA_R1_A01_01_ABI08.ab1 1 TTTTGGAAAG CCATTGGCCA CACCAGCCAC CACCTTCTGA TAGGCAGCCT GCACCTGAGG 61 AGTGAATTGA TTATCGATTC TAGACTAGTT TAATTAATTT CTAGAGCGCT TAATGGCTAA 121 TCGCCATCTT CCAGCAGGCG CACCATTGCC CCTGTTTCAC TATCCAGGTT ACGGATATAG 181 TTCATGACAA TATTTACATT GGTCCAGCCA CCAGCTTGCA TGATCTCCGG TATTGAAACT 241 CCAGCGCGGG CCATATCTCG CGCGGCTCCG ACACGGGCAC TGTGTCCAGA CCAGGCCAGG 301 TATCTCTGAC CAGAGTCATC CTTAGCGCCG TAAATCAATC GATGAGTTGC TTCAAAAATC 361 CCTTCCAGGG CGCGAGTTGA TAGCTGGCTG GTGGCAGATG GCGCGGCAAC ACCATTTTTT 421 CTGACCCGGC AAAACAGGTA GTTATTCGGA TCATCAGCTA CACCAGAGAC GGAAATCCAT 481 CGCTCGACCA GTTTAGTTAC CCCCAGGCTA AGTGCCTTCT CTACACCTGC GGTGCTAACC 541 AGCGTTTTCG TTCTGCCAAT ATGGATTAAC ATTCTCCCAC CGTCAGTACG TGAGATATCT 601 TTAACCCTGA TCCTGGCAAT TTCGGCTATA CGTAACAGGG TGTTATAAGC AATCCCCAGA 661 AATGCCAGAT TACGTATATC CTGGCAGCGA TCGCTATTTT CCATGAGTGA ACGAACCTGG 721 TCGAAATCAG TGCGTTCGAA CGCTAGAGCC TGTTTTGCAC GTTCACCGGC ATCAACGTTT 781 TCTTTTCGGA TCCGCCGCAT AACCAGTGAA ACAGCATTGC TGTCACTTGG TCGTGGCAGC 841 CCGGACCGAC GATGAAGCAT GTTTAGCTGG CCCAAATGTT GCTGGGATAG TTTTTTACTG 901 CCAGACCGCG CGCCTGAAGA TATAGGAAGA TAATCGCGAA CATCTTTCAG GTTCTGCGGG 961 AAACCCATTT CCCGGTTATT CAACTTTGCA CCATGCCGCC ACGACCGGGC AAAACGGACA 1021 GAGGCATTTT CCAGTAATGC TTCAGAAACC GCCTTGGCCG AATCCCTGGA CCATGGTCAT 1081 TCAGTCTGCG ACCTCATCAA CTCGATTG //
Primer: CMV_en_R Sequence file: RDB01748_020904d.seq
>01748_01748_A6C4-7_3_CMV_en_R_C01_03_ABI08.ab1 1 TCGTGGAATT ACTATTAATA ACTAGTCAAT AATCAATGTC GACATCGGTT TAAACGATTG 61 TCGACTCGCG ACGATGGATC TGGAAGGTGC TGAGGTACGA TGAGACCCGC ACCAGGTGCA 121 GACCCTGCGA GTGTGGCGGT AAACATATTA GGAACCAGCC TGTGATGCTG GATGTGACCG 181 AGGAGCTGAG GCCCGATCAC TTGGTGCTGG CCTGCACCCG CGCTGAGTTT GGCTCTAGCG 241 ATGAAGATAC AGATTGAGGT ACTGAAATGT GTGGGCGTGG CTTAAGGGTG GGAAAGAATA 301 TATAAGGTGG GGGTCTTATG TAGTTTTGTA TCTGTTTTGC AGCAGCCGCC GCCGCCATGA 361 GCACCAACTC GTTTGATGGA AGCATTGTGA GCTCATATTT GACAACGCGC ATGCCCCCAT 421 GGGCCGGGGT GCGTCAGAAT GTGATGGGCT CCAGCATTGA TGGTCGCCCC GTCCTGCCCG 481 CAAACTCTAC TACCTTGACC TACGAGACCG TGTCTGGAAC GCCGTTGGAG ACTGCAGCCT 541 CCGCCGCCGC TTCAGCCGCT GCAGCCACCG CCCGCGGGAT TGTGACTGAC TTTGCTTTCC 601 TGAGCCCGCT TGCAAGCAGT GCAGCTTCCC GTTCATCCGC CCGCGATGAC AAGTTGACGG 661 CTCTTTTGGC ACAATTGGAT TCTTTGACCC GGGAACTTAA TGTCGTTTCT CAGCAGCTGT 721 TGGATCTGCG CCAGCAGGTT TCTGCCCTGA AGGCTTCCTC CCCTCCCAAT GCGGTTTAAA 781 ACATAAATAA AAAACCAGAC TCTGTTTGGA TTTGGATCAA GCAAGTGTCT TGCTGTCTTT 841 ATTTAGGGGT TTTGCGCGCG CGGTAGGCCC GGGGACCAGC GGTCTCGGGT CGTTGAGGGT 901 CCTGTGTATT TTTTTCCAGG ACGTGGTAAA GGTGACTCTG GGATGTTCAG ATACATGGGG 961 CATAAGCCCG GTCTCTGGGG TGGGAGGGTA GCACCACTGC AGAGCTTTCA TGCTGCGGGG 1021 TGTTGTTGTA GATGATTCCA GTCGTAGCAA GAAGCGGCTG GCCGTTGCAT GGCTAAAAAT 1081 TGTTCGTTTC AGTAGCCAAG C //

Please visit Sequencing and PCR primers for primer information.

References

Original, user report and related articles

original	Kanegae, Y., Efficient gene activation system on mammalian cell chromosomes using recombinant adenovirus producing Cre recombinase. Gene, 181, 207-212 (1996). PMID 8973332.
original	Kanegae, Y., Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res., 23, 3816-3821 (1995). PMID 7479022.
reference	Hosoya, M., Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss. Cell Rep. 18 (1): 68-81 (2017). PMID 28052261.
reference	Danno, S., PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts. Genes Cells 22 (2): 220-236 (2017) PMID 28102564.
reference	Sato, T., JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration. Cell Death Differ. 22 (8): 1260-1274 (2015). PMID 25571974.
reference	Tuvshintugs, B., JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis. Genes Cells 19 (9): 692-703 (2014). PMID 25130574.
reference	Fukamachi, K., A novel reporter rat strain that expresses LacZ upon Cre-mediated recombination. Genesis, 51 (4): 268-274 (2013). PMID 23349063.
reference	Niwa, H., Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene, 108 (2): 193-200 (1991). PMID 1660837.
user report	Morimoto, H., ROS amplification drives mouse spermatogonial stem cell self-renewal. Life Sci. Alliance 2 (2). pii: e201900374 (2019). PMID 30940732.
user report	Morita, M., PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. Cancer Cell 33 (3): 355-367.e7 (2018). PMID 29533781.
user report	Watanabe, S., In Vivo Genetic Manipulation of Spermatogonial Stem Cells and Their Microenvironment by Adeno-Associated Viruses. Stem Cell Reports 10 (5): 1551-1564 (2018). PMID 29628393.
user report	Salah, M., An in vitro system to characterize prostate cancer progression identified signaling required for self-renewal. Mol. Carcinog. 55 (12): 1974-1989 (2016). PMID 26621780.
user report	Chanmee, T., Hyaluronan Production Regulates Metabolic and Cancer Stem-like Properties of Breast Cancer Cells via Hexosamine Biosynthetic Pathway-coupled HIF-1 Signaling. J. Biol. Chem. 291 (46): 24105-24120 (2016). PMID 27758869.
user report	Kanatsu-Shinohara, M., Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal. Genes Dev. 30 (23): 2637-2648 (2016). PMID 28007786.
user report	Kurihara, C., An easy method for preparation of Cre-loxP regulated fluorescent adenoviral expression vectors and its application for direct reprogramming into hepatocytes. Biotechnol. Rep. (Amst.) 12: 26-32 (2016). PMID 28352551.
user report	Tanaka, T., The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage. J. Reprod. Dev. 61 (4): 305-316 (2015). PMID 25959802.
user report	Kanatsu-Shinohara, M., Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal. Proc. Natl. Acad. Sci. U.S.A., 111 (24): 8826-8831 (2014). PMID 24879440.
user report	Matsushita, Y., Microglia activation precedes the anti-opioid BDNF and NMDA receptor mechanisms underlying morphine analgesic tolerance. Curr. Pharm. Des. 19 (42): 7355-7361 (2013). PMID 23448475.
user report	Egawa, N., The E1 protein of human papillomavirus type 16 is dispensable for maintenance replication of the viral genome. J. Virol., 86 (6): 3276-3283 (2012). PMID 22238312.
user report	Kumadaki, S., Inhibition of Ubiquitin ligase F-box and WD repeat domain-containing 7(alpha) (Fbw7(alpha}) causes hepatosteatosis through the Kruppel-like factor 5 (KLF5)/PPAR(gamma)2 pathway, but not SREBP-1c in mice. J. Biol. Chem., 286 (47): 40835-40846 (2011). PMID 21911492.
user report	Nodagashira T., Efficient Gene Transduction in HER2-Expressing Cells by Two Recombinant Adenovirus Vectors with HER2 Promotor and Cre/loxP System. Hirosaki Med. J., 61: 26-34 (2010).
user report	Takashima, S., Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects. Biol. Reprod., 81, 155-164 (2009). PMID 19228594.
user report	Deurholt T., Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes. BMC Biotechnol., 9: 89 (2009). PMID 19845959.
user report	Kanatsu-Shinohara, M., Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Cell Stem Cell, 3 (5): 533-542 (2008). PMID 18983968.
user report	Tomimatsu N., Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks. J. Biol. Chem., 282, 10138-10145 (2007). PMID 17272272.
user report	Takehashi, M., Adenovirus-mediated gene delivery into mouse spermatogonial stem cells. Proc. Natl. Acad. Sci. U. S. A., 104 (8): 2596-2601 (2007). PMID 17299052.
user report	Dali-Youcef N., Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure. Proc. Natl. Acad. Sci. U S A., 104, 10703-10708 (2007). PMID 17556545.
user report	Omoteyama K., Activation of connective tissue growth factor gene by the c-Maf and Lc-Maf transcription factors. Biochem. Biophys. Res. Commun., 339, 1089-1097 (2006). PMID 16343439.
user report	Sakaki-Yumoto M., The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Development, 133, 3005-3013 (2006). PMID 16790473.
user report	Hoekstra R., Assessment of in vitro applicability of reversibly immortalized NKNT-3 cells and clonal derivatives. Cell Transplant., 15, 423-433 (2006). PMID 16970284.
user report	Gao Z., Delection of the PDGFR-beta Gene Affects Key Fibroblast Functions Important for Wound Healing J. Biol. Chem., 280, 9375-9389 (2005). PMID 15590688.
user report	Yanagihara M., Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs. Cancer Sci., 96, 620-6 (2005). PMID 16128748.
user report	Tanaka S., Mitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation. J. Neurochem., 95, 179-190 (2005). PMID 16181422.
user report	Nishitai G., Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells. J. Biol. Chem., 279, 1621-1626 (2004). PMID 14585831.
user report	Mizukami H., Separate control of Rep and Cap expression using mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production. Mol. Biotechnol., 27, 7-14 (2004). PMID 15122043.
user report	Matsuura K., Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle. J. Cell Biol., 167, 351-363 (2004). PMID 15492039.
user report	Aihara M., Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin gene. Lab. Invest., 84, 1581-1592 (2004). PMID 15502861.
user report	Suzuki K., Adenovirus-mediated gene transfer of interferon alpha improves dimethylnitrosamine-induced liver cirrhosis in rat model. Gene Ther., 10, 765-773 (2003). PMID 12704415.
user report	Furuyama T., Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation. Biochem. J., 375, 365-371 (2003). PMID 12820900.
user report	Nishioka K., Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells. Int. J. Oncol., 23, 925-32 (2003). PMID 12963970.
user report	Noguchi H., Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization. Hum. Gene Ther., 13, 321-334 (2002). PMID 11812287.
user report	Iida A., Cytoplasmic RNA vector derived from nontransmissible Sendai virus. Production and use. Methods Mol. Med., 69, 361-370 (2002). PMID 11987789.
user report	Kaartinen V., TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis. Int. J. Mol. Med., 9, 563-70 (2002). PMID 12011971.
user report	Ohba Y., Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. EMBO J., 20, 3333-3341 (2001). PMID 11432821.
user report	Fukazawa T., Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells. Oncogene, 20, 5225-5231 (2001). PMID 11526513.
user report	Kobayashi N., Cre/loxP-based reversible immortalization of human hepatocytes. Cell Transplant., 10, 383-386 (2001). PMID 11549058.
user report	Yokoo T., Inflamed glomeruli-specific gene activation that uses recombinant adenovirus with the Cre/loxP system. J. Am. Soc. Nephrol., 12, 2330-2337 (2001). PMID 11675409.
user report	Kaartinen V., Removal of the floxed neo gene from a conditional knockout allele by the adenoviral Cre recombinase in vivo. Genesis., 31, 126-129 (2001). PMID 11747203.
user report	Araki T., Shp-2 specifically regulates several tyrosine-phosphorylated proteins in brain-derived neurotrophic factor signaling in cultured cerebral cortical neurons. Neurochem., 74, 659-668 (2000). PMID 10646517.
user report	Kobayashi N., Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes. Science, 287, 1258-1262 (2000). PMID 10678831.

2022.02.09

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